Dan Drezner isn’t buying rumors that al-Qaeda has an unspecified supply of tactical nuclear weapons, but recommends vigilence nonetheless; the Belgravia Dispatch has similar thoughts.
I don’t have anything to add to either analysis; it seems rather implausible that the group would have such weapons yet not use them—if not against the United States, then certainly against Israel, which would seem to be an easier target. To paraphrase the Dispatch, terror groups generally aren’t known for their strategic geopolitical wherewithal, and mutually-assured destruction is pretty meaningless as a deterrent when your territory is a few hundred square miles of borderline-uninhabitable territory to begin with and you have a martyr complex to boot.